Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Microarray analysis of human A549 lung cancer cells treated with brefeldin A, golgicide A, monensin or vehicle control for 8 h or 20 h

ABSTRACT: A549 cells were treated for 8 or 20 h using 20 ng/mL brefeldin A (BFA), 5 µM golgicide A (GCA), 10 µM monensin (MON) or the appropriate vehicle control (BFA/EtOH, MON/EtOH, GCA/DMSO).

ORGANISM(S): Homo sapiens

SUBMITTER: Jan Baumann 

PROVIDER: E-MTAB-5627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing.

Baumann Jan J   Ignashkova Tatiana I TI   Chirasani Sridhar R SR   Ramírez-Peinado Silvia S   Alborzinia Hamed H   Gendarme Mathieu M   Kuhnigk Kyra K   Kramer Valentin V   Lindemann Ralph K RK   Reiling Jan H JH  

Molecular biology of the cell 20171108 1

The secretory pathway is a major determinant of cellular homoeostasis. While research into secretory stress signaling has so far mostly focused on the endoplasmic reticulum (ER), emerging data suggest that the Golgi itself serves as an important signaling hub capable of initiating stress responses. To systematically identify novel Golgi stress mediators, we performed a transcriptomic analysis of cells exposed to three different pharmacological compounds known to elicit Golgi fragmentation: brefe  ...[more]

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