RNA-seq of TGF-beta induced and histone variant H2A.Z-knocked-down canine MDCK cells in epithelial-to-mesenchymal transition (EMT)

ABSTRACT: Our group is interested in epithelial-to-mesenchymal transition (EMT), in particular, TGF-beta induced EMT. TGF-beta signalling has been shown to be an important factor in the induction of EMT and it has been demonstrated that adding TGF-beta to epithelial cells in culture is a convenient way to study the process of EMT. “In response to TGF-beta, Smad2 and 3 are activated, and form complexes with Smad4, which then regulate transcription of target genes through interactions with other DNA binding transcription factors. In the induction of EMT, the activated Smads mediate transcriptional regulation through three families of transcription factors, resulting in repression of epithelial marker gene expression and activation of mesenchymal gene expression” (Xu J, et al. 2009)

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INSTRUMENT(S): NextSeq 500

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Sebastian Kurscheid 

PROVIDER: E-MTAB-5628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress