SNP array in severe early-onset obesity

ABSTRACT: Obesity is considered a multifactorial disorder with high heritability (50-75%), probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including CNVs, have been defined, the genetic causes underlying the disease still remain largely unknown. We aimed to identify novel genetic and genomic abnormalities in a cohort of Spanish children with severe non-syndromic early-onset obesity (EOO). We obtained molecular karyotypes of 157 children with EOO. Large and rare CNVs were validated and segregated in the family. A higher burden of duplication-type CNVs was detected in EOO patients versus controls (OR=1.85, p-value=0.008).

ORGANISM(S): Homo sapiens

SUBMITTER: Clara Serra Juhé 

PROVIDER: E-MTAB-5680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress