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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression data from 10 untreated human colon cancer cell lines

ABSTRACT: Omega-3 polyunsaturated fatty acids are normal constituents of the diet and have an essential role in maintaining important cellular functions. Docosahexaenoic acid (DHA) have demonstrated anticancer activities in several in vitro and in vivo studies, and in some clinical studies. The mechanism by which n-3 PUFAs reduce tumor growth probably involves the inhibition of cell proliferation, induction of cell death, or a combination of both. There are differences in sensitivity towards DHA treatment among colorectal cell lines, although the reason why is unclear. 10 human colorectal cell lines, representing 5 different subtypes of colorectal cancer, were included in gene expression analysis. (Pleae refer to Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, et al. “A colorectal cancer classification system that associates cellular phenotype and responses to therapy”. Nat Med. 2013;19:619-625. doi:10.1038/nm.3175 for details on cancer subtype classifications.) Our aim is to identify different levels of genes and pathways correlating with differences in sensitivity towards DHA between the colorectal cell lines for future classification of patients that could benefit from omega-3 PUFA treatment in addition to conventional treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Helle Samdal

PROVIDER: E-MTAB-5750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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