A five-microRNA-signature predicting recurrence in HNSCC

ABSTRACT: The risk of locoregional or distant failure in advanced HPV-negative head and neck squamous cell carcinoma (HNSCC) patients is high. However, no suitable markers for stratification are clinically available. Thus, we aimed to identify a microRNA(miRNA)-signature predicting disease recurrence. For this purpose the miRNA profiles from 162 HNSCC samples were analysed with regard to identification of a low-complex porgnostic signature. The data set consists of a discovery dataset (n=85) and a validation dataset (n=77). The study resulted in a prognostic 5-miRNA signature significantly predicting the relevant clinical endpoint freedom from recurrence.

ORGANISM(S): Homo sapiens

SUBMITTER: Kristian Unger 

PROVIDER: E-MTAB-5793 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress