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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-Seq of Group 2 innate lymphoid cells (ILC2) from lung and lymph node

ABSTRACT: Group 2 innate lymphoid cells (ILC2) promote the production of a type-2 immunological environment in the uterus and have tissue-specific gene signatures that change with pregnancy.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Russell Hamilton

PROVIDER: E-MTAB-5806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-Seq of Group 2 innate lymphoid cells (ILC2) from uterine tissue (Virgin, E9.5, E18.5)

Project description:Group 2 innate lymphoid cells (ILC2) promote the production of a type-2 immunological environment in the uterus and have tissue-specific gene signatures that change with pregnancy.

2023-04-15 | E-MTAB-5803 | biostudies-arrayexpress

Classical dendritic cells are required for dietary antigen-mediated peripheral regulatory T cell and tolerance induction II

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2016-03-28 | E-GEOD-77304 | biostudies-arrayexpress

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Classical dendritic cells are required for dietary antigen-mediated peripheral regulatory T cell and tolerance induction

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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The transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells (ILCs) and maintenance of type 2 ILCs

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Total RNA sequencing for Mus musculus bone marrow lymphoid committed cell populations

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2022-11-19 | E-MTAB-11217 | biostudies-arrayexpress

Expression data from TFIIA-non-cleavable mouse fetal liver hematopoietic stem cells

Project description:During embryogenesis, development of hematopoietic stem cells (HSC) occurs in the fetal liver and involves coordinate programs of transcription. Taspase1, a highly conserved threonine protease, directly cleaves and regulates the TFIIA families of transcription factors. We discovered that loss of Taspase1 (Tasp1-/-) or non-cleavage of TFIIAa-b (TFIIAa-b nc/nc) leads to a severe fetal liver developmental retardation that is associated with impaired HSC self-renewal and loss of HSC quiescence. We used microarray to elucidate the mechanism(s) by which TFIIA regulates fetal liver hematopoiesis, and expression of targets of HoxA9 was found to be altered by gene set enrichment analyses. Embryonic day 14.5 fetal liver HSCs (defined as Lineage-Sca-1+c-Kit+CD150+cells) of wild-type (n = 4) and TFIIAa-b nc/nc (n = 3) were analyzed.

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