ChIP-Seq mapping of histone modifications at multiple DNA Double Strand Breaks

ABSTRACT: DNA Double Strands Breaks (DSBs) are highly detrimental since they can lead to mutations and chromosomes rearrangements (amplification, deletion, translocation and chromosome loss). Here, we used in a standardized system, where multiples DSBs are induced at defined positions across the human genome (U2OS-DIvA cells), to describe the distribution of eighteen histone modifications before and after damage using ChIP-Seq. This provides a comprehensive picture of the chromatin landscape induced at DSBs.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Marion Aguirrebengoa 

PROVIDER: E-MTAB-5817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress