Inter and intra-lineage genetic diversity of Zika virus differs for American isolates

ABSTRACT: Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. ZIKV infections are associated with neurodevelopmental deficiencies termed Congenital Zika Syndrome. ZIKV strains are grouped into three phylogenetic lineages: East African, West African, and Asian, which contains the American lineage. RNA virus genomes exist as genetically-related sequences. The heterogeneity of these viral populations is implicated in viral fitness, and genome diversity is correlated to virulence. This study examines genetic diversity of representative ZIKV strains from all lineages utilizing next generation sequencing (NGS). Inter-lineage diversity results indicate that ZIKV lineages differ broadly from each other; however, intra-lineage comparisons of American ZIKV strain

INSTRUMENT(S): Illumina HiSeq 1500

ORGANISM(S): Zika virus

SUBMITTER: Natalie Collins 

PROVIDER: E-MTAB-5945 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress