Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of Bacillus subtilis treated with plectasin

ABSTRACT: transriptional profiling of Bacillus subtilis treated with Plectasin

ORGANISM(S): Bacillus subtilis strain 168

SUBMITTER: Allan Nielsen

PROVIDER: E-MTAB-60 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.

Schneider Tanja T Kruse Thomas T Wimmer Reinhard R Wiedemann Imke I Sass Vera V Pag Ulrike U Jansen Andrea A Nielsen Allan K AK Mygind Per H PH Raventós Dorotea S DS Neve Søren S Ravn Birthe B Bonvin Alexandre M J J AM De Maria Leonardo L Andersen Anders S AS Gammelgaard Lora K LK Sahl Hans-Georg HG Kristensen Hans-Henrik HH

Science (New York, N.Y.) 20100501 5982

Host defense peptides such as defensins are components of innate immunity and have retained antibiotic activity throughout evolution. Their activity is thought to be due to amphipathic structures, which enable binding and disruption of microbial cytoplasmic membranes. Contrary to this, we show that plectasin, a fungal defensin, acts by directly binding the bacterial cell-wall precursor Lipid II. A wide range of genetic and biochemical approaches identify cell-wall biosynthesis as the pathway tar ...[more]

PMID: 20508130

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Dataset Information

Transcription profiling of Bacillus subtilis treated with plectasin

Publications

Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.

Similar Datasets

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