An application of a systems toxicology approach using a human organotypic small airway cultures for a comparative assessment between a candidate modified-risk tobacco product aerosol and cigarette smoke.

ABSTRACT: Along the trachea-bronchial tree, including the small airway region, cigarette smoke exposure induces inflammation, which can exacerbate the development of chronic obstructive pulmonary disease (COPD). The small airway region is known as the primary location of airway blockage in COPD and asthma. Therefore, evaluating exposure impact on the small airway is relevant for risk assessment. Using an in vitro human small airway culture model and a Systems Toxicology approach, this present study reports an assessment of the biological impact of an aerosol from a candidate modified-risk tobacco product, tobacco heating system (THS) 2.2, as compared with 3R4F smoke, at similar nicotine concentratng other functional measures (e.g., cytotoxicity, ciliary beating function, secretion of pro-inflammato

ORGANISM(S): Homo sapiens

SUBMITTER: Alain Sewer 

PROVIDER: E-MTAB-6004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress