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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Biochemical Efficacy and Safety Trial of Vitamin D: dose-finding, placebo-controlled, randomised clinical trial assessing effects of high dose vitamin D

ABSTRACT: The overall aim was to investigate the effects of low and high dose vitamin D supplementation on genome-wide gene expression and how this is modulated by genetic variation. We adopted a functional genomics approach to analyse study participants in the BEST-D clinical trial (placebo, low dose or high dose supplementation over a 12-month treatment period).

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Berlanga-Taylor

PROVIDER: E-MTAB-6246 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estimation of the optimum dose of vitamin D for disease prevention in older people: rationale, design and baseline characteristics of the BEST-D trial.

Clarke Robert R Newman Connie C Tomson Joseph J Hin Harold H Kurien Rijo R Cox Jolyon J Lay Michael M Sayer Jenny J Hill Michael M Emberson Jonathan J Armitage Jane J

Maturitas 20150207 4

<h4>Background</h4>Previous large trials of vitamin D for prevention of fractures and other disease outcomes have reported conflicting results, possibly because the doses tested were insufficient to maintain optimum blood levels of vitamin D (25[OH]D) predicted by the observational studies. This report describes the design and baseline characteristics of the BEST-D (Biochemical Efficacy and Safety Trial of vitamin D) trial which aims to establish the best dose of vitamin D to assess in a future ...[more]

PMID: 25721698

Publication: 1/3

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