Microglia have a more extensive and divergent response to interferon-alpha compared with astrocytes

ABSTRACT: Type I interferons (IFN-I) are crucial for effective antimicrobial defence in the central nervous system (CNS) but also can cause severe neurological disease (termed cerebral interferonopathy) as exemplified by Aicardi-Goutières Syndrome and chronic viral infection. In the CNS, microglia and astrocytes have essential roles in host responses to infection and injury, with both cell types responding to IFN-I. However, the extent to which the IFN-I responses of these cells differ, if at all, is still unknown. Here we determined the global transcriptional responses of astrocytes and microglia to the IFN-I, IFN-alpha. MGCs were prepared from 2–4 day-old C57BL/6 mice. Purified primary astrocytes were obtained from the MGCs by magnetic activated cell sorting using anti-CD11b beads. Microglia wer

ORGANISM(S): Mus musculus

SUBMITTER: Wen Li 

PROVIDER: E-MTAB-6301 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress