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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Methylation arrays (MethylationEPIC) reveal specific DNA hypermethylation of T cells during human hematopoietic differentiation

ABSTRACT: Epigenetic regulation plays an important role in cellular development and differentiation. A detailed map of the DNA methylation dynamics that occur during cell differentiation would contribute to decipher the molecular networks governing cell fate commitment. We used the most recent Illumina MethylationEPIC Beadchip platform to describe the genome-wide DNA methylation changes observed throughout hematopoietic maturation by analyzing multiple hematopoietic cell types at different developmental stages. We identified a plethora of DNA methylation changes that occur during human hematopoietic differentiation. Interestingly, we observed that T lymphocytes display a substantial enhancement of de novo CpG hypermethylation as compared to other hematopoietic cell populations.

ORGANISM(S): Homo sapiens

SUBMITTER: Agustin F. Fernández

PROVIDER: E-MTAB-6315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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