Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis to decipher molecular mechanism in early lung toxicity induced by low-LET photon and high-LET carbon-ions in mouse model


ABSTRACT: The time factor in the development of radiation induced lung fibrosis is important but not well characterized so far. This study was to investigate the time series of acute-, subacute-, early and late- timepoints after exposure with low-LET photons versus proton versus and high-LET carbon-ions. The role of CTGF inhibitor in modulating inflammation related signaling pathways were also studied at the acute timepoints. The potential mechanisms underlining the time-dependent progression of inflammatory and fibrotic response is to be illustrated in the present study.

ORGANISM(S): Mus musculus

SUBMITTER: Cheng Zhou 

PROVIDER: E-MTAB-6420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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