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Investigation of placental DNA methylation in obese women exposed to Metformin during pregnancy

ABSTRACT: Maternal obesity in pregnancy is associated with increased birth-weight, obesity and premature mortality in adult offspring. The Effect of Metformin on Maternal and Fetal Outcomes in Pregnant Obese Women (EMPOWaR) trial was a randomised, double-blind, placebo-controlled trial carried out to determine whether exposure to Metformin would affect the offspring birth-weight centile. Obese women exposed to Metformin had increased insulin sensitivity at 36 weeks of pregnancy, but there were no differences in offspring birthweight. We obtained the placentas from these women to determine whether there were differences in DNA methylation of genes regulating fetal growth and metabolism. In a related study we investigated the gene expression in the same samples.

INSTRUMENT(S): Ilumina HiScan H166

ORGANISM(S): Homo sapiens

SUBMITTER: Jane Norman 

PROVIDER: E-MTAB-6421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Background</h4>Maternal obesity is associated with high birthweight, obesity and premature mortality in adult offspring, probably as a result of maternal hyperglycaemia and insulin resistance. We present the results of a trial designed to test the hypothesis that metformin will improve insulin sensitivity in obese pregnant women, thereby reducing the incidence of high-birthweight babies.<h4>Objective</h4>To determine the efficacy of metformin (up to 2500 mg daily) given to obese pregnant wom  ...[more]

PMID: 27606384

Publication: 1/2

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