IPSC-derived macrophages effectively treat pulmonary alveolar proteinosis in Csf2rb-deficient mice

ABSTRACT: The key aim of this experiment is to characterize the iPSC-Mφ population before and after pulmonary transplantation. For this purpose the following cell populations were compared: (i) transplanted iPSC-Mφ, (ii) Mφ obtained by in vitro differentiation of murine lineage-negative bone marrow cells (BM-Mφ), (iii) non-differentiated CD45.1 iPSC, (iv) murine alveolar Mφ (AMφ) isolated from the BALF of healthy control mice, and (v) iPSC-Mφ recovered from the transplanted animals two months after (PMT-Mφ).

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Henning Kempf 

PROVIDER: E-MTAB-6442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress