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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Cell-of-origin epigenetic signatures are maintained during colorectal carcinogenesis

ABSTRACT: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and therefore provide novel opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importantly, colorectal carcinomas could be classified into the same methylation subtypes, reflecting their shared cell-types of origin with adenomas. Further data analysis also revealed significantly reduced overall survival for one of the subtypes. Our results establish a novel concept for understanding the methylation patterns observed in colorectal cancer and provide opportunities for tumor subclassification and patient stratification.

ORGANISM(S): Homo sapiens

SUBMITTER: Frank Lyko

PROVIDER: E-MTAB-6450 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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