Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis

ABSTRACT: 36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Peri-meniscal synovium was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The generated data served to identify the molecular pathophysiology present in inflamed synovium during the early development of post-traumatic osteoarthritis (PTOA), as well as differences between surgical treatments.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Sus scrofa

SUBMITTER: Jakob Sieker 

PROVIDER: E-MTAB-6664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress