Transcriptional profiling of Dicer conditional knockout hematopoietic stem cells.

ABSTRACT: Gene expression of HSC (Lin-Sca-Kit+Flt3-) hematopoietic stem cells from Dicer D/+ mice was compared with LT-HSC from DicerD/D mice. BM cells were noncompetitively transplanted into irradiant recipients, and deletion induced by poly(IC) injection. Donor-derived HSCs were isolated by FACS sorting of recipient bone marrow. Biological replicates of each (2 per genotype) were generated and expression profiles were determined by hybridization to Affymetrix Moe430_2 arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Claus Nerlov 

PROVIDER: E-MTAB-674 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress