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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional response to Rosiglitazone in adipocyte progenitors isolated from WT and Cited4-KO scWAT

ABSTRACT: Lin-Sca-1+ adipocyte progenitors from subcutaneous adipose tissue of wild-type and Cited4-/- female mice were cultured under conditions promoting general adipogenic differentiation or beige/brite adipocyte differentiation (treatment with Rosi). Cells were harvested 48 post-induction of differentiation.

ORGANISM(S): Mus musculus

SUBMITTER: Alex Vegiopoulos

PROVIDER: E-MTAB-6796 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.

Bayindir-Buchhalter Irem I Wolff Gretchen G Lerch Sarah S Sijmonsma Tjeerd T Schuster Maximilian M Gronych Jan J Billeter Adrian T AT Babaei Rohollah R Krunic Damir D Ketscher Lars L Spielmann Nadine N Hrabe de Angelis Martin M Ruas Jorge L JL Müller-Stich Beat P BP Heikenwalder Mathias M Lichter Peter P Herzig Stephan S Vegiopoulos Alexandros A

EMBO molecular medicine 20180801 8

Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious insulin sensitization. However, a better understanding of the context-specific PPARg responses is required for the development of novel approaches with reduced side effects. Here, we identified the tr ...[more]

PMID: 29973382

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