CGH analysis of human colorectal carcinoma HCT116 cells that escaped from entescence

ABSTRACT: The engulfment of live cells by other live cells, also known as cannibalism, can result in the death of engulfed cells. Recently, we show that autophagy favors the accumulation of E-cadherins on the surface of cannibal cells, thereby enhancing their capacity to engulf and eliminate live cells. Importantly, cannibal cells exhibited genomic instability and activated a senescence program that we termed “entescence”. In breast cancer patients, neoadjuvant chemotherapy response was associated with the induction of entescence. Conversely, the suppression of entescence by dominant negative mutants of p53 favored the proliferation of aneuploid cannibal cells and predicts cancer progression. Our data indicate that entescence is a non-cell-autonomous program of senescence that compromises cancer de

ORGANISM(S): Homo sapiens

SUBMITTER: Jean-Luc Perfettini 

PROVIDER: E-MTAB-6802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress