JAK2V617F mutant HSC microarray

ABSTRACT: Mutant JAK2V617F is found in majority of patients with myeloproliferative neoplasm. While heterozygous JAK2V617F induced an ET-like phenotype, JAK2V617F homozygosity drives an severe PV-like phenotype in knock-in mice. HSCs from mice with homozygous JAK2V617F expression show impaired self-renewal in transplants. To understand the molecular mechanisms involved this HSC functional defect, microarray was performed on isolated LT-HSCs from mice expressing wildtype, heterozygous and homozygous expression of mutant JAK2.

ORGANISM(S): Mus musculus

SUBMITTER: Anthony Green 

PROVIDER: E-MTAB-6878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress