Transcriptomic profiling of spinal and bulbar muscular atrophy cultured embryonic motor neurons

ABSTRACT: Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s Disease, is a slowly progressive adult-onset neuromuscular disease which results from a polyglutamine (polyQ) encoding CAG repeat expansion within the androgen receptor gene (AR). Despite the ubiquitous expression of the androgen receptor, it is unclear why motor neurons selectively degenerate and there are no effective treatments or disease modifying therapies for this debilitating disease. In order to identify potential therapeutic targets, we set out to establish the genes and molecular pathways involved in early motor neuron dysfunction in SBMA. We therefore undertook global transcriptomic profiling of cultured primary embryonic motor neurons from the spinal cord of AR100 mice, which model SBMA.. Four biological replica

ORGANISM(S): Mus musculus

SUBMITTER: Bilal Malik 

PROVIDER: E-MTAB-6986 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress