Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analyses of a C. glabrata strain deleted for the transcription factor Aft2.

ABSTRACT: In these experiments, we compared the transcriptomes of a wild type strain and an aft2 deleted strain of the pathogenic yeast Candida glabrata. The comparisons were performed in four different growth conditions: iron starvation (BPS treatment), selenite treatment, cadmium treatment and optimal growth conditions (YPD).

ORGANISM(S): [Candida] glabrata

SUBMITTER: Frederic Devaux 

PROVIDER: E-MTAB-7042 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative Transcriptomics Highlights New Features of the Iron Starvation Response in the Human Pathogen <i>Candida glabrata</i>.

Benchouaia Médine M   Ripoche Hugues H   Sissoko Mariam M   Thiébaut Antonin A   Merhej Jawad J   Delaveau Thierry T   Fasseu Laure L   Benaissa Sabrina S   Lorieux Geneviève G   Jourdren Laurent L   Le Crom Stéphane S   Lelandais Gaëlle G   Corel Eduardo E   Devaux Frédéric F  

Frontiers in microbiology 20181116

In this work, we used comparative transcriptomics to identify regulatory outliers (ROs) in the human pathogen <i>Candida glabrata</i>. ROs are genes that have very different expression patterns compared to their orthologs in other species. From comparative transcriptome analyses of the response of eight yeast species to toxic doses of selenite, a pleiotropic stress inducer, we identified 38 ROs in <i>C. glabrata</i>. Using transcriptome analyses of <i>C. glabrata</i> response to five different s  ...[more]

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