The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori

ABSTRACT: We performed a transcriptome analysis of two Helicobacter pylori wild-type strains and their corresponding mutants lacking a highly conserved GCGC-specific m5C-MTase (JHP1050) that was predicted to be active in all of 459 H. pylori genome sequences analyzed. Transcriptome data revealed that m5C-methylation modifies the transcription of multiple genes related to adherence to host cells, natural competence for DNA uptake or susceptibility to copper.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Helicobacter pylori

SUBMITTER: Sebastian Suerbaum 

PROVIDER: E-MTAB-7162 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress