Transcription profiling by array of MG-63 cells grown on different biomaterials used in bone grafts

ABSTRACT: During the past decades, there have been major advances in the field of biomaterials, thereby generating a vast variety of materials for a broad range of tissue engineering and regeneration applications. Although gene expression profiling has been used occasionally in biomaterial research, its usefulness for understanding cell-biomaterial interactions should be further explored for it to fulfill its promise as a tool to assess and improve material properties. Here, the transcriptional landscape induced by 23 materials is explored with a variety of properties within the scope of bone regeneration. An osteoblast cell line is used to identify the gene expression profiles that can be adopted in response to biophysical and chemical cues. It is shown that TGF-beta and WNT signaling may be involv

ORGANISM(S): Homo sapiens

SUBMITTER: Jan de Boer 

PROVIDER: E-MTAB-7219 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress