Exome sequencing of human ex vivo ovarian cancer models with matched stromal cells

ABSTRACT: Ascites or solid tumour from patients with ovarian cancer was collected and grown in culture as ex vivo models. Each sample has a mixture of tumour and stromal cells which were separated into individual cultures. Therefore each patient has tumour and stromal cultures originating from the same tissue collection. Variant calling (exome-seq) analysis was performed on these matched models to establish tumour specific mutations. Stromal cells were used to rule out germline mutations.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Taylor 

PROVIDER: E-MTAB-7225 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress