Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Effects of anti-androgenic compounds on zebrafish insulin mutants


ABSTRACT: Aiming to identify insulin-independent modulators of glucose homeostasis, we performed a drug screen on zebrafish insulin (ins) mutants and identified androgen receptor (AR) antagonists. To investigate how AR antagonism mediates glucose level reduction in ins mutants, we evaluated the effects of antagonist treatment using transcriptomic studies. RNA-Seq analyses were performed on 120 hours post fertilization (hpf) ins mutants treated with Flutamide or Cyproterone starting at 84 hpf compared to vehicle (DMSO) treated mutants.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Danio rerio

SUBMITTER: Sri Teja Mullapudi 

PROVIDER: E-MTAB-7283 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2022-01-14 | E-MTAB-10167 | biostudies-arrayexpress
2014-09-30 | E-GEOD-52652 | biostudies-arrayexpress
2015-08-06 | E-GEOD-71681 | biostudies-arrayexpress
2016-06-27 | E-GEOD-70623 | biostudies-arrayexpress
2016-03-29 | E-GEOD-74197 | biostudies-arrayexpress
2021-12-01 | E-MTAB-9193 | biostudies-arrayexpress
2014-06-01 | E-GEOD-49186 | biostudies-arrayexpress
2013-04-01 | E-GEOD-37227 | biostudies-arrayexpress
2018-10-20 | E-MTAB-7282 | biostudies-arrayexpress
2016-07-03 | E-GEOD-52398 | biostudies-arrayexpress