DNA-methylation profiling of human induced pluripotent stem cell -derived intestinal epithelial organoids

ABSTRACT: The purpose of this study was to characterise iPSC-derived human intestinal epithelial organoids (iPSCo) by comparing these cultures with primary purified intestinal epithelial cells (IEC). Intestinal epithelial organoid (IEO) cultures were derived from at least three different lines of iPSCs, DNA was extracted and gene expression was profiled using Illumina Infinium HumanMethylation450Beadarray. We compared these profiles with datasets we have previously derived from purified IEC from mature terminal ileum (TI) and sigmoid colon (SC) as well as human fetal proximal gut (FPG) and fetal distal gut (FDG).

ORGANISM(S): Homo sapiens

SUBMITTER: Judith Kraiczy 

PROVIDER: E-MTAB-7289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress