Whole embryo RNA-seq of 73 mouse mutant lines and baseline controls from the Mouse Genetics Project (DMDD)

ABSTRACT: The Deciphering the Mechanisms of Developmental Disorders (DMDD) programme analyses the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines. Here we show that single whole embryo RNA-seq of 73 mouse mutant lines (>1000 transcriptomes) uncovers transcriptional events underlying embryonic lethality and associates previously uncharacterised genes with specific pathways and tissues. Further, we separate embryonic delay signatures from line-specific transcriptional changes by developing a baseline mRNA expression catalogue of wild-type mice during somitogenesis. Collectively, this work provides a rich resource to further our understanding of early embryonic developmental disorders.

INSTRUMENT(S): Illumina HiSeq 2500, Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Elisabeth Busch-Nentwich 

PROVIDER: E-MTAB-7322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress