High content imaging in the screening of biomaterial-induced MSC behavior

ABSTRACT: Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analytical methods involve assessing commonly used markers for a predefined readout, masking the actual situation induced in the cells. Hence, a broader expression profile of the cellular response should be envisioned, which technically limits up scaling to higher throughput systems. However, it is increasingly recognized that morphometric readouts, obtained non-invasively, are related to gene expression patterns. Here, we introduced distinct surface roughness to three PLA surfaces, by exposure to ox

ORGANISM(S): Homo sapiens

SUBMITTER: Dennie Hebels 

PROVIDER: E-MTAB-7352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress