RNA-seq of E. coli strains overproducing DNA \\"damage-up\\" proteins (DDPs)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina MiSeq
ORGANISM(S): Escherichia coli K-12
SUBMITTER: Devon Fitzgerald
PROVIDER: E-MTAB-7361 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.
Xia Jun J Chiu Li-Ya LY Nehring Ralf B RB Bravo Núñez María Angélica MA Mei Qian Q Perez Mercedes M Zhai Yin Y Fitzgerald Devon M DM Pribis John P JP Wang Yumeng Y Hu Chenyue W CW Powell Reid T RT LaBonte Sandra A SA Jalali Ali A Matadamas Guzmán Meztli L ML Lentzsch Alfred M AM Szafran Adam T AT Joshi Mohan C MC Richters Megan M Gibson Janet L JL Frisch Ryan L RL Hastings P J PJ Bates David D Queitsch Christine C Hilsenbeck Susan G SG Coarfa Cristian C Hu James C JC Siegele Deborah A DA Scott Kenneth L KL Liang Han H Mancini Michael A MA Herman Christophe C Miller Kyle M KM Rosenberg Susan M SM
Cell 20190101 1-2
DNA damage provokes mutations and cancer and results from external carcinogens or endogenous cellular processes. However, the intrinsic instigators of endogenous DNA damage are poorly understood. Here, we identify proteins that promote endogenous DNA damage when overproduced: the DNA "damage-up" proteins (DDPs). We discover a large network of DDPs in Escherichia coli and deconvolute them into six function clusters, demonstrating DDP mechanisms in three: reactive oxygen increase by transmembrane ...[more]
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