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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional Profiling of Human Airway Smooth muscle cells from subjects with and without asthma-effects of mimicking viral challenge

ABSTRACT: This experiment was to have a look at the transcriptional profiles from subjects with and without asthma following viral challenge, using Polyinosinic:polycytidylic acid (Poly IC) which is a synthetic analog of double-stranded RNA (dsRNA), a molecular pattern associated with viral infection.

ORGANISM(S): Homo sapiens

SUBMITTER: Amanda Sutcliffe

PROVIDER: E-MTAB-7406 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma.

Sutcliffe Amanda A Hollins Fay F Gomez Edith E Saunders Ruth R Doe Camille C Cooke Marcus M Challiss R A John RA Brightling Chris E CE

American journal of respiratory and critical care medicine 20111122 3

<h4>Rationale</h4>Asthma is characterized by disordered airway physiology as a consequence of increased airway smooth muscle contractility. The underlying cause of this hypercontractility is poorly understood.<h4>Objectives</h4>We sought to investigate whether the burden of oxidative stress in airway smooth muscle in asthma is heightened and mediated by an intrinsic abnormality promoting hypercontractility.<h4>Methods</h4>We examined the oxidative stress burden of airway smooth muscle in bronchi ...[more]

PMID: 22108207

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