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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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CLIP-seq analysis of C.elegans MINA-1::GFP transgenic animals.

ABSTRACT: Analysis to determine which mRNAs are specifically associated with MINA-1 protein.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Luca Ducoli

PROVIDER: E-MTAB-7420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans.

Sendoel Ataman A Subasic Deni D Ducoli Luca L Keller Martin M Michel Erich E Kohler Ines I Singh Kapil Dev KD Zheng Xue X Brümmer Anneke A Imig Jochen J Kishore Shivendra S Wu Yibo Y Kanitz Alexander A Kaech Andres A Mittal Nitish N Matia-González Ana M AM Gerber André P AP Zavolan Mihaela M Aebersold Ruedi R Hall Jonathan J Allain Frédéric H-T FH Hengartner Michael O MO

Cell death and differentiation 20190206 10

Post-transcriptional control of mRNAs by RNA-binding proteins (RBPs) has a prominent role in the regulation of gene expression. RBPs interact with mRNAs to control their biogenesis, splicing, transport, localization, translation, and stability. Defects in such regulation can lead to a wide range of human diseases from neurological disorders to cancer. Many RBPs are conserved between Caenorhabditis elegans and humans, and several are known to regulate apoptosis in the adult C. elegans germ line. ...[more]

PMID: 30728462

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