Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of neuronal SOX2-ablated murine suprachiasmatic nuclei against wild-type littermate controls


ABSTRACT: Mice lacking the stem/progenitor cell transcription factor, Sex determining region Y-box 2 (SOX2), in neurons of the suprachiasmatic nuclei display imprecise, poorly consolidated behavioral rhythms that do not entrain efficiently to environmental light cycles. RNA sequencing revealed that Sox2 deficiency alters the circadian transcriptome of the SCN, reducing the expression of many core clock genes and neuropeptide-receptor systems.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Arthur Hoi Hin Cheng 

PROVIDER: E-MTAB-7496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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