TP53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors

ABSTRACT: Our mechanistic studies shed light on the central role of the proto-oncogene MYC in driving global protein anabolism and the ER stress response. Specifically, the MYC-p19ARF-TP53 axis plays a critical role in regulating proteostasis and an increased demand for protein disposal.

ORGANISM(S): Mus musculus

SUBMITTER: Sahil Seth 

PROVIDER: E-MTAB-7497 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress