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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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KDM5C safeguards the appropriate timing of early neurodevelopment

ABSTRACT: We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differentiation based on “Yichen Shi et al. Nat. Protoc. 7, 1836–1846 (2012)” to define differences in gene expression between the Mutant and Corrected during neurodevelopment.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Violetta Karwacki-Neisius

PROVIDER: E-MTAB-7551 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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