FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias

ABSTRACT: Combined all trans retinoic acid (ATRA) / arsenic regimen cures virtually all acute promyelocytic leukemi (APL) patients. However, APL is often associated with activating FLT3-internal tandem duplication (ITD) mutation and the molecular bases for this effect remain unknown. Using mouse APL models, we demonstrate the FLT3-ITD severely blunts ATRA response.

ORGANISM(S): Mus musculus

SUBMITTER: Hugues De Thé 

PROVIDER: E-MTAB-7566 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress