Seminal plasma exposures strengthen vaccine responses in the female reproductive tract mucosae

ABSTRACT: HIV-1 sexual transmission occurs mainly via mucosal semen exposures. In the female reproductive tract (FRT), seminal plasma (SP) induces physiological modifications, including inflammation. An effective HIV-1 vaccine should elicit mucosal immunity. However, modifications of vaccine responses by the local environment remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized the impact of HIV-1+ SP intravaginal exposure on the local immune responses of nonhuman primates. Multiple HIV-1+ SP exposures did not impact the anti-MVA antibody responses. However, SP exposures revealed an anti-MVA responses mediated by CD4+ T cells, which was not observed in the control group. Multi-parameter approaches clearly identified the cervix as the most impa

ORGANISM(S): Macaca fascicularis

SUBMITTER: Romain Marlin 

PROVIDER: E-MTAB-7639 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress