Transcriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.

ABSTRACT: PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous JAK2V617F-dependet inflammatory footprint at the transcriptome level.

ORGANISM(S): Homo sapiens

SUBMITTER: Jiri Bartek 

PROVIDER: E-MTAB-7693 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress