NK cell immune responses differ after prime and boost vaccination

ABSTRACT: A better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified vaccinia virus Ankara using cynomolgus macaques as a model. Mass cytometry was used to deeply characterize blood NK cells. The NK cell subphenotype composition was modified by the prime. Certain phenotypic changes induced by the prime were maintained over time and, as a result, the NK cell composition prior to boost differed from that before prime. The key phenotypic signature that distinguished NK cells responding to the boost from those responding to the prime included stronger expression of several cytotoxic, homing, and adhesion molecules, suggesting that NK c

ORGANISM(S): Macaca fascicularis

SUBMITTER: Anne-Sophie Beignon 

PROVIDER: E-MTAB-7697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress