Unknown,Transcriptomics,Genomics,Proteomics

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Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination


ABSTRACT: Whole blood transcriptomics analysis of healthy individuals, immunized with the trivalent 2012-2013 season flu vaccine via transcutaneous, intramuscular or intradermal route. We define an early gene expression profile, detected at day 1 after immunization, that is associated with the development of either humoral or cytotoxic CD8 T cell responses. We used System Biology approach to analyse vaccine efficacy in order to find innate predictive biomarkers of the quality of adaptive responses for potential clinical use in the future. Moreover, from a methodological point of view this study increases knowledges on how vaccine route(s) can affect resulting immune responses and into mechanisms involved in the induction of humoral and cellular immunity to influenza vaccination.

ORGANISM(S): Homo sapiens

SUBMITTER: Elena Goncalves 

PROVIDER: E-MTAB-7741 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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