RNA-seq, ATAC-seq and DNA-methylation array data of human oligodendrocyte-like cells derived from transdifferentiated fibroblasts

ABSTRACT: One-step reprogramming of human fibroblasts into oligodendrocyte-like cells. We characterized the expression, chromatin accessibility and methylation profile of human oligodendrocyte-like cells derived using a new protocol for the direct transdifferentiation of human fibroblasts into oligodendrocyte-like cells. Direct conversion of fibroblasts was induced by ectopic overexpression of SOX10, OLIG2 and NKX6.2. The aim of the experiments was to characterise the transcriptional response and associated chromatin changes following transdifferentiation. In addition, profiles of primary human oligodendrocytes were produced.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Benjamín Hernández-Rodríguez 

PROVIDER: E-MTAB-7838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress