Transcriptional profiling of human paediatric CD8+ T-cells in Inflammatory Bowel Diseases

ABSTRACT: Differences in CD8+ T-cell expression have previously been reported to correlate with disease outcome in adult patients diagnosed with Inflammatory Bowel Diseases (IBD). In addition, T-cell exhaustion was found to be associated with a milder disease course in adults. The purpose of this study was to test the prognostic value of the reported adult T-cell expression and exhaustion signatures in a cohort of children newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC). We also investigated the possibility of a paediatric specific prognostic expression signature.

ORGANISM(S): Homo sapiens

SUBMITTER: Felicity Payne 

PROVIDER: E-MTAB-7923 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress