Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic profiling of mutant and WT HNF4alpha hepatic progenitor stage cells


ABSTRACT: During mammalian development, liver differentiation is driven by signals which converge on multiple transcription factor networks. The hepatocyte nuclear factor signalling network is known to be essential for hepatocyte specification and maintenance. In these studies we demonstrate that nuclear HNF4a is essential for hepatic progenitor specification and the introduction of point mutations in HNF4a’s SUMO consensus motif leads to disrupted hepatocyte specification and maturation.

ORGANISM(S): Homo sapiens

SUBMITTER: Wolfgang Schmidt-Heck 

PROVIDER: E-MTAB-7951 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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