Gamma radiation induces Life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis

ABSTRACT: In the current study a systematic investigation of life stage, tissue and cell dependent sensitivity to ionizing radiation in the nematode Caenorhabditis elegans was conducted. This revealed that individuals that have reached the post-mitotic L4 stage showed no significant effects with respect to mortality, morbidity or reproduction when subjected to either acute dose ≤6 Gy(1500 mGy/h) or chronic exposure ≤4 Gy( ≤ 100 mGy/h). In contrast, chronic exposure from embryo to young adult stage caused a dose and dose rate dependent reprotoxicitiy with 43% reduction in total brood size at 6.7Gy (107 mGy/h). Systematic targeted irradiation of developmental stages showed that exposure during L1 to young L4 was sufficient to induce reprotoxic effects. Exposure during these stages was associated with

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Fabian Grammes 

PROVIDER: E-MTAB-8004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress