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Using ribosome profiling to investigate the effect of p53 on translation in cancer cells

ABSTRACT: p53 is deleted or dysfunctional, or develops these features during the course of disease, with a frequency of about 50% in human cancers. This is clinically important because this group of patients respond very poorly to treatment. Our approach to discovering novel biomarkers or targets for therapy for p53 deleted/dysfunctional disease is to find genes that are translationally regulated by p53. The aim of this experiment is to compare translational efficiencies in cancer cells that are p53 WT, p53-/-, or p53 R175H, in response to doxorubicin.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Anne Willis

PROVIDER: E-MTAB-8100 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BRD7 is a candidate tumour suppressor gene required for p53 function

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Structural Assessment of the Full-Length Tumor Suppressor Protein p53 by Mass Spectrometry-Guided Computational Modeling

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RNA-seq of H1299 cells stably transfected with empty vector or the p53 mutant R273H.

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Human p53 interating protein ID

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