Transcriptional profiling by array of yeast to identify genes inhibiting mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

ABSTRACT: Haplo-insufficiency profiling followed by Gene-set enrichment analysis of sensitive strains was conducted in yeast treated with tigecycline. This revealed significant enrichment of genes involved in mitochondrial translation, similar to that seen with the known mitochondrial translation inhibitors chloramphenicol and linezolid

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Lawrence Heisler 

PROVIDER: E-MTAB-814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress