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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Repeated exposure and switching study of cigarette smoke and next generation tobacco product using 3D human bronchial epithelial cells

ABSTRACT: Next generation product such as heat-not-burn type product and e-cigarette emit lower yields of chemical constituents than cigarette because combustion of tobacco leaves is not associated with their vapor generation. Therefore it is expected that the usage of these product bring beneficial impact on public health. However, risk-reduced potential as well as risk concerns in long-term use of these products has not yet been fully understood. In this study, we intended to estimate the risk reduced potential of our proprietary novel tobacco vapor product (NTV) by repeated exposure of in vitro 3D bronchial epithelial cells to NTV vapor in comparison with repeated exposure to cigarette smoke. In addition, to reflect the realistic situation of smokers, exposure switching from cigarette smoke to NTV vapor and cigarette smoke exposure cessation were conducted.

ORGANISM(S): Homo sapiens

SUBMITTER: Shinkichi Ishikawa

PROVIDER: E-MTAB-8155 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Organotypic human bronchial epithelial cultures (MucilAir) exposed to mainstream aerosols from the 3R4F cigarette and a novel tobacco vapor product

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