A CellAge epigenetic clock for expedited discovery of anti-ageing compounds in vitro

ABSTRACT: We aim to improve anti-ageing drug discovery, currently achieved through laborious and lengthy longevity analysis. Recent studies demonstrated that the most accurate molecular method to measure human age is based on CpG methylation profiles, as exemplified by several epigenetics clocks that can accurately predict an individual’s age. Here, we developed CellAge, a new epigenetic clock that measures subtle ageing changes in primary human cells in vitro. As such it provides a unique tool to measure effects of relatively short pharmacological treatments on ageing. We validated our CellAge clock against known longevity drugs such as rapamycin and trametinib. Moreover, we uncovered novel anti-ageing drugs, torin2 and Dactolisib (BEZ-235), demonstrating the value of our approach as a screening an

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Lowe 

PROVIDER: E-MTAB-8327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress